Loading

Error: Cannot Load Popup Box

Hit List

Title:

Tu sombra. Aprende a conocer tu lado oscuro : aprende a desarrollarte

Publisher:

Paidós

Document Type:

book

URL:

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor

Author:

Description:

Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen. Extracellular matrix degradation is mediated by aggrecanases and matrix metalloproteinases (MMPs). Recently, a number of endogenous matrix molecules, including fibronectin (FN...

Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen. Extracellular matrix degradation is mediated by aggrecanases and matrix metalloproteinases (MMPs). Recently, a number of endogenous matrix molecules, including fibronectin (FN), have been implicated in mediating cartilage degradation. We were interested in studying the C-terminal heparin-binding region of FN since it mediates aggrecan and type II collagen breakdown in cartilage, but the specific FN domains responsible for proteolytic enzyme activity and their receptors in cartilage are unknown. In this study, the ability of recombinant FN domains to induce cartilage breakdown was tested. We found that the FN III 13-14 domains in the C-terminal heparin-binding region of FN are potent inducers of aggrecanase activity in articular cartilage. In murine studies, the FN III 13-14-induced aggrecanase activity was inhibited in Toll-like receptor 4 (TLR4) knockout mice but not wild-type mice. FN III 13-14 domains also synergized with the known catabolic cytokines interleukin-1α and tumour necrosis factor and induced secretion of MMP-1, MMP-3, gp38 and serum amyloid-like protein A in chondrocytes. Our studies provide a mechanistic link between the innate immune receptor TLR4 and sterile arthritis induced by the FN III 13-14 domains of the endogenous matrix molecule FN. Minimize

Publisher:

S. Karger AG

Year of Publication:

2011-12

Document Type:

Text

Language:

en

Subjects:

Research Article

Research Article Minimize

DDC:

616 Diseases *(computed)*

Rights:

Copyright © 2011 by S. Karger AG, Basel ; http://creativecommons.org/licenses/by-nc/3.0/ ; This article is distributed under the terms of the Creative Commons Attribution-Noncommercial License (http://creativecommons.org/licenses/by-nc/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided ...

Copyright © 2011 by S. Karger AG, Basel ; http://creativecommons.org/licenses/by-nc/3.0/ ; This article is distributed under the terms of the Creative Commons Attribution-Noncommercial License (http://creativecommons.org/licenses/by-nc/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. Minimize

URL:

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Girth six cubic graphs have Petersen minors

Author:

Description:

We prove that every 3-regular graph with no circuit of length less than six has a subgraph isomorphic to a subdivision of the Petersen graph. ; Comment: 12 pages, 2 figures

We prove that every 3-regular graph with no circuit of length less than six has a subgraph isomorphic to a subdivision of the Petersen graph. ; Comment: 12 pages, 2 figures Minimize

Year of Publication:

2014-05-02

Document Type:

text

Subjects:

Mathematics - Combinatorics ; Computer Science - Discrete Mathematics

Mathematics - Combinatorics ; Computer Science - Discrete Mathematics Minimize

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Linkless embeddings of graphs in $3$-space

Author:

Description:

We announce results about flat (linkless) embeddings of graphs in 3-space. A piecewise-linear embedding of a graph in 3-space is called {\it flat} if every circuit of the graph bounds a disk disjoint from the rest of the graph. We have shown: (i) An embedding is flat if and only if the fundamental group of the complement in 3-space of the embedd...

We announce results about flat (linkless) embeddings of graphs in 3-space. A piecewise-linear embedding of a graph in 3-space is called {\it flat} if every circuit of the graph bounds a disk disjoint from the rest of the graph. We have shown: (i) An embedding is flat if and only if the fundamental group of the complement in 3-space of the embedding of every subgraph is free. (ii) If two flat embeddings of the same graph are not ambient isotopic, then they differ on a subdivision of $K_5$ or $K_{3,3}$. (iii) Any flat embedding of a graph can be transformed to any other flat embedding of the same graph by ``3-switches'', an analog of 2-switches from the theory of planar embeddings. In particular, any two flat embeddings of a 4-connected graph are either ambient isotopic, or one is ambient isotopic to a mirror image of the other. (iv) A graph has a flat embedding if and only if it has no minor isomorphic to one of seven specified graphs. These are the graphs that can be obtained from $K_6$ by means of $Y\Delta$- and $\Delta Y$-exchanges. ; Comment: 6 pages Minimize

Year of Publication:

1992-12-31

Document Type:

text

Subjects:

Mathematics - Combinatorics ; Mathematics - Geometric Topology

Mathematics - Combinatorics ; Mathematics - Geometric Topology Minimize

DDC:

511 General principles of mathematics *(computed)*

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Permanents, Pfaffian orientations, and even directed circuits

Author:

Description:

Given a 0-1 square matrix A, when can some of the 1's be changed to -1's in such a way that the permanent of A equals the determinant of the modified matrix? When does a real square matrix have the property that every real matrix with the same sign pattern (that is, the corresponding entries either have the same sign or are both zero) is nonsing...

Given a 0-1 square matrix A, when can some of the 1's be changed to -1's in such a way that the permanent of A equals the determinant of the modified matrix? When does a real square matrix have the property that every real matrix with the same sign pattern (that is, the corresponding entries either have the same sign or are both zero) is nonsingular? When is a hypergraph with n vertices and n hyperedges minimally nonbipartite? When does a bipartite graph have a "Pfaffian orientation"? Given a digraph, does it have no directed circuit of even length? Given a digraph, does it have a subdivision with no even directed circuit? It is known that all of the above problems are equivalent. We prove a structural characterization of the feasible instances, which implies a polynomial-time algorithm to solve all of the above problems. The structural characterization says, roughly speaking, that a bipartite graph has a Pfaffian orientation if and only if it can be obtained by piecing together (in a specified way) planar bipartite graphs and one sporadic nonplanar bipartite graph. ; Comment: 47 pages, published version Minimize

Year of Publication:

1999-10-31

Document Type:

text

Subjects:

Mathematics - Combinatorics

Mathematics - Combinatorics Minimize

DDC:

511 General principles of mathematics *(computed)*

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Excluded minors in cubic graphs

Author:

Description:

Let G be a cubic graph, with girth at least five, such that for every partition X,Y of its vertex set with |X|,|Y|>6 there are at least six edges between X and Y. We prove that if there is no homeomorphic embedding of the Petersen graph in G, and G is not one particular 20-vertex graph, then either G\v is planar for some vertex v, or G can be dr...

Let G be a cubic graph, with girth at least five, such that for every partition X,Y of its vertex set with |X|,|Y|>6 there are at least six edges between X and Y. We prove that if there is no homeomorphic embedding of the Petersen graph in G, and G is not one particular 20-vertex graph, then either G\v is planar for some vertex v, or G can be drawn with crossings in the plane, but with only two crossings, both on the infinite region. We also prove several other theorems of the same kind. ; Comment: 62 pages, 17 figures Minimize

Year of Publication:

2014-03-09

Document Type:

text

Subjects:

Mathematics - Combinatorics

Mathematics - Combinatorics Minimize

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Predicting the likelihood of voiced complaints in the self-service technology context

Description:

There is considerable evidence to suggest that consumer dissatisfaction with self-service technologies is widespread. However, there has been little conceptual or empirical scrutiny of the likelihood that consumers will complain to an organization (likelihood of voice) in this context. This study contributes to the service domain by testing empi...

There is considerable evidence to suggest that consumer dissatisfaction with self-service technologies is widespread. However, there has been little conceptual or empirical scrutiny of the likelihood that consumers will complain to an organization (likelihood of voice) in this context. This study contributes to the service domain by testing empirically a model of the antecedents of consumers' likelihood of voice in unsatisfactory encounters with self-service technologies. A model is tested that combines established antecedents of voice, such as likelihood of voice success, and those that have not yet been considered, including self-service technology powerlessness and need to vent. The results support the proposed model in general. Theoretical and managerial implications of the findings are discussed. Minimize

Publisher:

Sage Publications

Year of Publication:

2009-08-01

Document Type:

Journal Article

Language:

eng

Subjects:

Consumer voice ; self-service technologies ; complaint management ; consumer dissatisfaction

Consumer voice ; self-service technologies ; complaint management ; consumer dissatisfaction Minimize

Rights:

2009, The Author(s)

2009, The Author(s) Minimize

Relations:

http://dro.deakin.edu.au/eserv/DU:30020748/robertson-predictingthelikelihood-2009.pdf

URL:

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Conceptualizing the ιnfluence of the self-service technology context on consumer voice

Description:

The self-service technology (SST) context is characterized by consumer participation in service production and delivery, independent of service personnel; a lack of interpersonal interaction between consumers and service personnel; and consumers being required tointerface and interact with technology. With these features of the SST context in mi...

The self-service technology (SST) context is characterized by consumer participation in service production and delivery, independent of service personnel; a lack of interpersonal interaction between consumers and service personnel; and consumers being required tointerface and interact with technology. With these features of the SST context in mind, in situations where SSTs fail to perform as promised, some challenges arise: consumers who are dissatisfied do not have the security or reassurance of service personnel to assist them; service personnel do not have the opportunity to prompt consumers to voice their dissatisfaction; and consumers need to initiate their own complaint response. If consumers fail to report their dissatisfaction directly to the organization, organizations will not know that a problem exists and may experience negative consequences such as consumer switching behavior. As reports of consumer dissatisfaction with SSTs become increasingly common, it is important, therefore, to investigate how organizations with SST-based offerings can encourage consumers to voice their dissatisfaction directly to the organization. Although the antecedents of consumer voice are well documented in the interpersonal services context, in the context of SSTs they have been subject to very little conceptual or empirical scrutiny. This paper argues that voice needs to be revisited with respect to SSTs due to their unique characteristics compared to interpersonal services, and presents a conceptual model of the antecedents of consumers' voice behavior in the context of SSTs. Minimize

Publisher:

Hapworth Press Inc.

Year of Publication:

2006-01-01

Document Type:

Journal Article

Language:

eng

Subjects:

consumer voice ; self-service technologies ; consumer complaining behavior ; attribution of blame ; venting ; complaint communication

consumer voice ; self-service technologies ; consumer complaining behavior ; attribution of blame ; venting ; complaint communication Minimize

DDC:

303 Social processes *(computed)*

Rights:

2005, Hapworth Press

2005, Hapworth Press Minimize

Relations:

http://dro.deakin.edu.au/eserv/DU:30003882/robertson-conceptualizingthe-2005.pdf

URL:

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Aaron Copland : a guide to research

Description:

xii, 216 p. ; 23 cm. ; A bibliographic guide with annotations. Guides the user to primary and secondary sources on Aaron Copland (life, history, compositions and writings). ; Divided into nine sections. The first, "A Guide to Studies on Aaron Copland," introduces the research guide. The second section, "Chronology of Life and Works," contains a ...

xii, 216 p. ; 23 cm. ; A bibliographic guide with annotations. Guides the user to primary and secondary sources on Aaron Copland (life, history, compositions and writings). ; Divided into nine sections. The first, "A Guide to Studies on Aaron Copland," introduces the research guide. The second section, "Chronology of Life and Works," contains a well-organized timeline that presents significant biographical events, writings, and compositions chronologically in three columns. Section three, "Primary Sources," is the most substantial; it is a comprehensive list, with annotations, of Copland's published and unpublished books, articles, essays, and interviews. Section four contains secondary sources that are general studies, while section five contains secondary sources that are specifically about Copland's compositions. Section six, "Topical Studies," contains secondary sources relating to Copland as an Americanist, a conductor, a critic, an author, and a teacher. Each bibliographic section is prioritized by research significance. Section seven lists tributes and obituaries (no annotations), section eight lists foreign language sources (only one), and section nine lists bibliographies and discographies. Three indexes are included: one for authors, one for composition titles, and one for subjects. ; Extensive annotations accompany each entry. The guide also identifies areas in which research is lacking. For example, the entry under "Copeland as Mentor/Teacher" reads, "We could find no exhaustive texts written about Copland's role as a mentor."Extensive annotations accompany each entry. The guide also identifies areas in which research is lacking. For example, the entry under "Copeland as Mentor/Teacher" reads, "We could find no exhaustive texts written about Copland's role as a mentor." ; The organization by "bibliographic importance" within each section is a subjective method. It could be helpful to research, but often makes it difficult to identify materials by date or by author. Minimize

Publisher:

Routledge

Year of Publication:

2001

Source:

Garland composer resource manuals, vol. 53 ; Robertson, Marta and Robin Armstrong. Aaron Copland: A Guide to Research. Composer Resource Manual, no. 53. New York and London: Routledge, 2001.

Garland composer resource manuals, vol. 53 ; Robertson, Marta and Robin Armstrong. Aaron Copland: A Guide to Research. Composer Resource Manual, no. 53. New York and London: Routledge, 2001. Minimize

Language:

English

Subjects:

Composer Thematic Catalogue-Bibliography; Copland ; Aaron ; 1900- --Bibliography.; Compositions; Composers; Twentieth century; Aaron Copland; United States;

Composer Thematic Catalogue-Bibliography; Copland ; Aaron ; 1900- --Bibliography.; Compositions; Composers; Twentieth century; Aaron Copland; United States; Minimize

DDC:

780 Music *(computed)*

URL:

Content Provider:

My Lists:

My Tags:

Notes:

Title:

Non-pharmacological management of fever in otherwise healthy children

Description:

Background: Fever is a common childhood problem faced in both hospital and community settings. In many cases the fever is associated with mild to moderate self-limiting illnesses. There has been a rapid increase in antipyretic use as the means of managing or treating this adaptive physiological response to infection. The use of alternative means...

Background: Fever is a common childhood problem faced in both hospital and community settings. In many cases the fever is associated with mild to moderate self-limiting illnesses. There has been a rapid increase in antipyretic use as the means of managing or treating this adaptive physiological response to infection. The use of alternative means of caring for a febrile child could minimise the amount of antipyretics administered to children and thereby reduce the potential risks. Objective: The objective of this systematic review was to establish what non-pharmacological practices are effective in managing fever in children, three months to 12 years of age, who are otherwise healthy. Inclusion criteria: Interventions for inclusion were physiological e.g. maintenance of hydration and rest, and external cooling, either direct e.g. sponging, clothing, or environmental e.g. fans, ambient temperature. Outcomes of interest were effect on fever, increase in comfort, decrease in parental anxiety and reduction in unnecessary use of health services. Search strategy: The search sought English, Spanish, Portuguese, Mandarin and Italian language studies, published 2001-2011 in 12 major databases. Critical appraisal, data extraction and data synthesis:Critical appraisal of and data extraction from eligible studies were undertaken using standardised tools developed by the Joanna Briggs Institute. As statistical pooling of data was precluded, the findings are presented in narrative form. ; Results: Twelve randomised controlled trials were included, involving 986 children in total. Only one intervention identified in the review protocol – direct external cooling measures – was addressed by the studies. Eleven studies included sponging as an intervention while one also included clothing (unwrapping). No studies investigated physiological interventions, (e.g. hydration or rest), or environmental cooling measures, (e.g. fans or ambient temperature) as separate interventions. Three of these interventions (encouragement of fluid intake, rest and fans) were reported as part of the standard care provided to participants in several studies or were controlled in the study (ambient temperature). Only two of the four outcomes identified in the review protocol were examined (effect on fever (all 12 studies) and patient comfort). Although tepid sponging alone resulted in an immediate decrease in temperature, this response was of short duration, with antipyretics or antipyretics plus sponging having a more lasting effect. In addition, the observed levels of discomfort of the sponged children were higher than the other groups. For both measures, this effect was not statistically significant in every case. ; Conclusion: The care of a febrile child needs to be individualised, based on current knowledge of the effectiveness and risks of interventions. The administration of antipyretics should be minimised, used selectively and with caution, even in otherwise healthy children. The results of this systematic review support previous findings that routine tepid sponging does not have an overall beneficial effect. However measures such as encouraging fluid intake and unwrapping the child should be encouraged. Implications for practice: The two foci of care should be the child and the parents/primary caregiver. For the child, care should aim to support the body’s physiological responses i.e. maintain hydration, minimise use of antipyretics. Support the parents to reduce anxiety e.g. by involving them in care and providing appropriate education, particularly in respect to correct dosages of antipyretics. Implications for research: Given the now well demonstrated discomfort engendered by tepid sponging, its use in treating febrile children is no longer advocated and does not warrant further research. However aspects of other non-pharmacological interventions have not been so well researched e.g. parental response to advice on fluid intake and appropriate clothing. Minimize

Publisher:

Curtin University of Technology

Year of Publication:

2012

Document Type:

Journal (Paginated)

Subjects:

fever ; child ; non-pharmacological interventions ; systematic review

fever ; child ; non-pharmacological interventions ; systematic review Minimize

DDC:

360 Social problems & services; associations *(computed)*

URL:

Content Provider:

My Lists:

My Tags:

Notes:

Currently in BASE: 68,072,316 Documents of 3,307 Content Sources

http://www.base-search.net