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Title:

MR-Perfusionsmessungen am Myokard mit dem intravaskulären Kontrastmittel NC100150

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Ludwig-Maximilians-Universität München

Year of Publication:

2004-07-23

Document Type:

Dissertation ; NonPeerReviewed

Subjects:

Tierärztliche Fakultät

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http://edoc.ub.uni-muenchen.de/2476/

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Title:

A fixed point formula of Lefschetz type in Arakelov geometry II: a residue formula

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This is the second of a series of papers dealing with an analog in Arakelov geometry of the holomorphic Lefschetz fixed point formula. We use the main result of the first paper to prove a residue formula "`a la Bott" for arithmetic characteristic classes living on arithmetic varieties acted upon by a diagonalisable torus; recent results of Bismu...

This is the second of a series of papers dealing with an analog in Arakelov geometry of the holomorphic Lefschetz fixed point formula. We use the main result of the first paper to prove a residue formula "`a la Bott" for arithmetic characteristic classes living on arithmetic varieties acted upon by a diagonalisable torus; recent results of Bismut-Goette on the equivariant (Ray-Singer) analytic torsion play a key role in the proof. ; Comment: 20 pages Minimize

Year of Publication:

2001-05-11

Document Type:

text

Subjects:

Mathematics - Algebraic Geometry ; Mathematics - Differential Geometry ; 14G40 ; 58J52 ; 14C40 ; 14L30 ; 58J20 ; 14K15

Mathematics - Algebraic Geometry ; Mathematics - Differential Geometry ; 14G40 ; 58J52 ; 14C40 ; 14L30 ; 58J20 ; 14K15 Minimize

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Title:

A fixed point formula of Lefschetz type in Arakelov geometry IV: the modular height of C.M. abelian varieties

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We give a new proof of a slightly weaker form of a theorem of P. Colmez. This theorem gives a formula for the Faltings height of abelian varieties with complex multiplication by a C.M. field whose Galois group over $\bf Q$ is abelian; it reduces to the formula of Chowla and Selberg in the case of elliptic curves. We show that the formula can be ...

We give a new proof of a slightly weaker form of a theorem of P. Colmez. This theorem gives a formula for the Faltings height of abelian varieties with complex multiplication by a C.M. field whose Galois group over $\bf Q$ is abelian; it reduces to the formula of Chowla and Selberg in the case of elliptic curves. We show that the formula can be deduced from the arithmetic fixed point formula proved in the first paper of the series. Our proof is intrinsic in the sense that it does not rely on the computation of the periods of any particular abelian variety. ; Comment: 25 pages Minimize

Year of Publication:

2001-05-11

Document Type:

text

Subjects:

Mathematics - Algebraic Geometry ; Mathematics - Differential Geometry ; 11M06 ; 14K22 ; 14G40 ; 58G10 ; 58G26

Mathematics - Algebraic Geometry ; Mathematics - Differential Geometry ; 11M06 ; 14K22 ; 14G40 ; 58G10 ; 58G26 Minimize

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Title:

A fixed point formula of Lefschetz type in Arakelov geometry II : a residue formula

Year of Publication:

2002

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Title:

A fixed point formula of Lefschetz type in Arakelov geometry II: a residue . . .

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The Pennsylvania State University CiteSeerX Archives

Year of Publication:

2013-06-21

Source:

http://arxiv.org/pdf/math/0105098v1.pdf

http://arxiv.org/pdf/math/0105098v1.pdf Minimize

Document Type:

text

Language:

en

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Metadata may be used without restrictions as long as the oai identifier remains attached to it.

Metadata may be used without restrictions as long as the oai identifier remains attached to it. Minimize

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Title:

A fixed point formula of Lefschetz type in Arakelov geometry IV: the modular height of C.M. abelian varieties

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The Pennsylvania State University CiteSeerX Archives

Year of Publication:

2013-06-21

Source:

http://arxiv.org/pdf/math/0105101v1.pdf

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Document Type:

text

Language:

en

Rights:

Metadata may be used without restrictions as long as the oai identifier remains attached to it.

Metadata may be used without restrictions as long as the oai identifier remains attached to it. Minimize

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Title:

Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy

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The protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification plays an important role in skeletal muscle development and physiological function. In this study, bitransgenic mice were generated that overexpressed NCOATGK, an O-GlcNAcase-inactive spliced variant of the O-GlcNAcase gene, specifically in skeletal muscle using the muscle creatin...

The protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification plays an important role in skeletal muscle development and physiological function. In this study, bitransgenic mice were generated that overexpressed NCOATGK, an O-GlcNAcase-inactive spliced variant of the O-GlcNAcase gene, specifically in skeletal muscle using the muscle creatine kinase promoter. Expression of the chimeric enhanced green fluorescent protein-NCOATGK transgene caused an increase of cellular O-GlcNAc levels, along with the accumulation and activation of proapoptotic factors in muscles of bitransgenic mice. The consequence of overexpressing the transgene for a 2-wk period was muscle atrophy and, in some cases, resulted in the death of male mice. Muscle atrophy is a common complication of many diseases, some of which correlate markedly with high cellular O-GlcNAc levels, such as diabetes. Our study provides direct evidence linking muscle atrophy and the disruption of O-GlcNAcase activity. Minimize

Publisher:

American Physiological Society

Year of Publication:

2011-03

Document Type:

Text

Language:

en

Subjects:

Muscle Cell Biology and Cell Motility

Muscle Cell Biology and Cell Motility Minimize

DDC:

572 Biochemistry *(computed)*

Rights:

Copyright © 2011 the American Physiological Society

Copyright © 2011 the American Physiological Society Minimize

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Title:

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A

Author:

Kasperavičiūtė, Dalia ; Catarino, Claudia B. ; Matarin, Mar ; Leu, Costin ; Novy, Jan ; Tostevin, Anna ; Leal, Bárbara ; Hessel, Ellen V. S. ; Hallmann, Kerstin ; Hildebrand, Michael S. ; ...

Kasperavičiūtė, Dalia ; Catarino, Claudia B. ; Matarin, Mar ; Leu, Costin ; Novy, Jan ; Tostevin, Anna ; Leal, Bárbara ; Hessel, Ellen V. S. ; Hallmann, Kerstin ; Hildebrand, Michael S. ; Dahl, Hans-Henrik M. ; Ryten, Mina ; Trabzuni, Daniah ; Ramasamy, Adaikalavan ; Alhusaini, Saud ; Doherty, Colin P. ; Dorn, Thomas ; Hansen, Jörg ; Krämer, Günter ; Steinhoff, Bernhard J. ; Zumsteg, Dominik ; Duncan, Susan ; Kälviäinen, Reetta K. ; Eriksson, Kai J. ; Kantanen, Anne-Mari ; Pandolfo, Massimo ; Gruber-Sedlmayr, Ursula ; Schlachter, Kurt ; Reinthaler, Eva M. ; Stogmann, Elisabeth ; Zimprich, Fritz ; Théâtre, Emilie ; Smith, Colin ; O’Brien, Terence J. ; Meng Tan, K. ; Petrovski, Slave ; Robbiano, Angela ; Paravidino, Roberta ; Zara, Federico ; Striano, Pasquale ; Sperling, Michael R. ; Buono, Russell J. ; Hakonarson, Hakon ; Chaves, João ; Costa, Paulo P. ; Silva, Berta M. ; da Silva, António M. ; de Graan, Pierre N. E. ; Koeleman, Bobby P. C. ; Becker, Albert ; Schoch, Susanne ; von Lehe, Marec ; Reif, Philipp S. ; Rosenow, Felix ; Becker, Felicitas ; Weber, Yvonne ; Lerche, Holger ; Rössler, Karl ; Buchfelder, Michael ; Hamer, Hajo M. ; Kobow, Katja ; Coras, Roland ; Blumcke, Ingmar ; Scheffer, Ingrid E. ; Berkovic, Samuel F. ; Weale, Michael E. ; Delanty, Norman ; Depondt, Chantal ; Cavalleri, Gianpiero L. ; Kunz, Wolfram S. ; Sisodiya, Sanjay M. Minimize authors

Description:

Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities, manda...

Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities, mandating the search for better understanding and treatment. The cause of mesial temporal lobe epilepsy with hippocampal sclerosis is unknown, but there is an association with childhood febrile seizures. Several rarer epilepsies featuring febrile seizures are caused by mutations in SCN1A, which encodes a brain-expressed sodium channel subunit targeted by many anti-epileptic drugs. We undertook a genome-wide association study in 1018 people with mesial temporal lobe epilepsy with hippocampal sclerosis and 7552 control subjects, with validation in an independent sample set comprising 959 people with mesial temporal lobe epilepsy with hippocampal sclerosis and 3591 control subjects. To dissect out variants related to a history of febrile seizures, we tested cases with mesial temporal lobe epilepsy with hippocampal sclerosis with (overall n = 757) and without (overall n = 803) a history of febrile seizures. Meta-analysis revealed a genome-wide significant association for mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures at the sodium channel gene cluster on chromosome 2q24.3 [rs7587026, within an intron of the SCN1A gene, P = 3.36 × 10−9, odds ratio (A) = 1.42, 95% confidence interval: 1.26–1.59]. In a cohort of 172 individuals with febrile seizures, who did not develop epilepsy during prospective follow-up to age 13 years, and 6456 controls, no association was found for rs7587026 and febrile seizures. These findings suggest SCN1A involvement in a common epilepsy syndrome, give new direction to biological understanding of mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures, and open avenues for investigation of prognostic factors and possible prevention of epilepsy in some children with febrile seizures. Minimize

Publisher:

Oxford University Press

Year of Publication:

2013-10

Document Type:

Text

Language:

en

Subjects:

Original Articles

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Rights:

© The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. ; http://creativecommons.org/licenses/by/3.0/ ; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and r...

© The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain. ; http://creativecommons.org/licenses/by/3.0/ ; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Minimize

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Title:

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A

Author:

Kasperaviciute, Dalia ; Catarino, Claudia B. ; Matarin, Mar ; Leu, Costin ; Novy, Jan ; Tostevin, Anna ; Leal, Barbara ; Hessel, Ellen V. S. ; Hallmann, Kerstin ; Hildebrand, Michael S. ; ...

Kasperaviciute, Dalia ; Catarino, Claudia B. ; Matarin, Mar ; Leu, Costin ; Novy, Jan ; Tostevin, Anna ; Leal, Barbara ; Hessel, Ellen V. S. ; Hallmann, Kerstin ; Hildebrand, Michael S. ; Dahl, Hans-Henrik M. ; Ryten, Mina ; Trabzuni, Daniah ; Ramasamy, Adaikalavan ; Alhusaini, Saud ; Doherty, Colin P. ; Dorn, Thomas ; Hansen, Joerg ; Kraemer, Guenter ; Steinhoff, Bernhard J. ; Zumsteg, Dominik ; Duncan, Susan ; Kaelviaeinen, Reetta K. ; Eriksson, Kai J. ; Kantanen, Anne-Mari ; Pandolfo, Massimo ; Gruber-Sedlmayr, Ursula ; Schlachter, Kurt ; Reinthaler, Eva M. ; Stogmann, Elisabeth ; Zimprich, Fritz ; Theatre, Emilie ; Smith, Colin ; O'Brien, Terence J. ; Tan, K. Meng ; Petrovski, Slave ; Robbiano, Angela ; Paravidino, Roberta ; Zara, Federico ; Striano, Pasquale ; Sperling, Michael R. ; Buono, Russell J. ; Hakonarson, Hakon ; Chaves, Joao ; Costa, Paulo P. ; Silva, Berta M. ; da Silva, Antonio M. ; de Graan, Pierre N. E. ; Koeleman, Bobby P. C. ; Becker, Albert ; Schoch, Susanne ; von Lehe, Marec ; Reif, Philipp S. ; Rosenow, Felix ; Becker, Felicitas ; Weber, Yvonne ; Lerche, Holger ; Roessler, Karl ; Buchfelder, Michael ; Hamer, Hajo M. ; Kobow, Katja ; Coras, Roland ; Blumcke, Ingmar ; Scheffer, Ingrid E. ; Berkovic, Samuel F. ; Weale, Michael E. ; Delanty, Norman ; Depondt, Chantal ; Cavalleri, Gianpiero L. ; Kunz, Wolfram S. ; Sisodiya, Sanjay M. ; UK Brain Expression Consortium Minimize authors

Year of Publication:

2013

Source:

WOS

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Document Type:

Article

Language:

English

Subjects:

Epilepsy comprises several syndromes ; amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant ; and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities ; ma...

Epilepsy comprises several syndromes ; amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant ; and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities ; mandating the search for better understanding and treatment. The cause of mesial temporal lobe epilepsy with hippocampal sclerosis is unknown ; but there is an association with childhood febrile seizures. Several rarer epilepsies featuring febrile seizures are caused by mutations in SCN1A ; which encodes a brain-expressed sodium channel subunit targeted by many anti-epileptic drugs. We undertook a genome-wide association study in 1018 people with mesial temporal lobe epilepsy with hippocampal sclerosis and 7552 control subjects ; with validation in an independent sample set comprising 959 people with mesial temporal lobe epilepsy with hippocampal sclerosis and 3591 control subjects. To dissect out variants related to a history of febrile seizures ; we tested cases with mesial temporal lobe epilepsy with hippocampal sclerosis with (overall n = 757) and without (overall n = 803) a history of febrile seizures. Meta-analysis revealed a genome-wide significant association for mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures at the sodium channel gene cluster on chromosome 2q24.3 [rs7587026 ; within an intron of the SCN1A gene ; P = 3.36 x 10(-9) ; odds ratio (A) = 1.42 ; 95% confidence interval: 1.26-1.59]. In a cohort of 172 individuals with febrile seizures ; who did not develop epilepsy during prospective follow-up to age 13 years ; and 6456 controls ; no association was found for rs7587026 and febrile seizures. These findings suggest SCN1A involvement in a common epilepsy syndrome ; give new direction to biological understanding of mesial temporal lobe epilepsy with hippocampal sclerosis with febrile seizures ; and open avenues for investigation of prognosticfactors and possible prevention of epilepsy in some children with febrile seizures. Minimize

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