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Title:

Semi-parametric Inference for Regression Models Based on Marked Point Processes

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SUMMARY. We study marked point processes (MPP's) with an arbitrary mark space. First we develop some statistically relevant topics in the theory of MPP's admitting an intensity kernel t(dz), namely martingale results, central limit theorems for both the number n of objects under observation and the time t tending to in nity, the decomposition in...

SUMMARY. We study marked point processes (MPP's) with an arbitrary mark space. First we develop some statistically relevant topics in the theory of MPP's admitting an intensity kernel t(dz), namely martingale results, central limit theorems for both the number n of objects under observation and the time t tending to in nity, the decomposition into a local characteristic ( t � t(dz)) and a likelihood approach. Then we present semi-parametric statistical inference in a class of Aalen (1975)-type multiplicative regression models for MPP's as n!1, using partial likelihood methods. Furthermore, considering the case t!1,we study purely parametric M-estimators. Minimize

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The Pennsylvania State University CiteSeerX Archives

Year of Publication:

2008-08-14

Source:

http://epub.ub.uni-muenchen.de/1472/1/paper_78.pdf

http://epub.ub.uni-muenchen.de/1472/1/paper_78.pdf Minimize

Document Type:

text

Language:

en

Subjects:

Marked point process ; intensity kernel ; locally square integrable) martingale ; local characteristic ; partial likelihood ; M-estimator

Marked point process ; intensity kernel ; locally square integrable) martingale ; local characteristic ; partial likelihood ; M-estimator Minimize

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Metadata may be used without restrictions as long as the oai identifier remains attached to it.

Metadata may be used without restrictions as long as the oai identifier remains attached to it. Minimize

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Title:

Semi-parametric Inference for Regression Models Based on Marked Point Processes

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Introduction and Basic Definitions The monography by Andersen et al. (1993) presents a kind of canonical approach to the statistical analysis of point process models. It deals with multivariate point processes where each random event carries information on the occurrence time and the type of event, the latter being from a finite set E of alterna...

Introduction and Basic Definitions The monography by Andersen et al. (1993) presents a kind of canonical approach to the statistical analysis of point process models. It deals with multivariate point processes where each random event carries information on the occurrence time and the type of event, the latter being from a finite set E of alternatives. The theoretical fundament to multivariate point processes was laid - among others - by Jacod (1975), Bremaud (1981) and Dellacherie & Meyer (1982). There are applications, however, where an uncountable set E (e.g., E the set of real numbers) of alternatives - now called marks - is more appropriate, see Scheike (1994a,b), Murphy (1995) and Pruscha (1997). A mathematical foundation of marked point processes (MPP's) is given by Last and Brandt (1995), but this work does not contain all tools necessary for statistical analysis. The first goal of the present paper is to fill this gap. We Minimize

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The Pennsylvania State University CiteSeerX Archives

Year of Publication:

2009-04-13

Source:

ftp://ftp.stat.uni-muenchen.de/pub/sfb386/paper78.ps.Z

ftp://ftp.stat.uni-muenchen.de/pub/sfb386/paper78.ps.Z Minimize

Document Type:

text

Language:

en

Subjects:

Marked point process ; intensity kernel ; locally square integrable) martingale ; local characteristic ; partial likelihood ; M-estimator

Marked point process ; intensity kernel ; locally square integrable) martingale ; local characteristic ; partial likelihood ; M-estimator Minimize

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330 Economics *(computed)*

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Metadata may be used without restrictions as long as the oai identifier remains attached to it.

Metadata may be used without restrictions as long as the oai identifier remains attached to it. Minimize

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Title:

Semi-parametric Inference for Regression Models Based on Marked Point Processes

Author:

Description:

We study marked point processes (MPP's) with an arbitrary mark space. First we develop some statistically relevant topics in the theory of MPP's admitting an intensity kernel $\lambda_t(dz)$, namely martingale results, central limit theorems for both the number $n $ of objects under observation and the time $t $ tending to infinity, the decompos...

We study marked point processes (MPP's) with an arbitrary mark space. First we develop some statistically relevant topics in the theory of MPP's admitting an intensity kernel $\lambda_t(dz)$, namely martingale results, central limit theorems for both the number $n $ of objects under observation and the time $t $ tending to infinity, the decomposition into a local characteristic $(\lambda_t,\Phi_t(dz)) $ and a likelihood approach. Then we present semi-parametric statistical inference in a class of Aalen (1975)-type multiplicative regression models for MPP's as $n \to \infty$, using partial likelihood methods. Furthermore, considering the case $t \to \infty$, we study purely parametric M-estimators. Minimize

Year of Publication:

1997-01-01

Document Type:

doc-type:workingPaper ; Paper ; NonPeerReviewed

Subjects:

Sonderforschungsbereich 386 ; Sonderforschungsbereich 386 ; ddc:510

Sonderforschungsbereich 386 ; Sonderforschungsbereich 386 ; ddc:510 Minimize

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http://epub.ub.uni-muenchen.de/1472/1/paper_78.pdf ; Luhm, A. und Pruscha, H. (1997): Semi-parametric Inference for Regression Models Based on Marked Point Processes. Sonderforschungsbereich 386, Discussion Paper 78

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Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids.

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Phospholipid (PL) scramblase is a plasma membrane protein that mediates accelerated transbilayer migration of PLs upon binding Ca2+, facilitating rapid mobilization of phosphatidylserine to the cell surface upon elevation of internal Ca2+. In patients with Scott syndrome, a congenital bleeding disorder related to defective expression of membrane...

Phospholipid (PL) scramblase is a plasma membrane protein that mediates accelerated transbilayer migration of PLs upon binding Ca2+, facilitating rapid mobilization of phosphatidylserine to the cell surface upon elevation of internal Ca2+. In patients with Scott syndrome, a congenital bleeding disorder related to defective expression of membrane coagulant activity, circulating blood cells show decreased cell surface exposure of phosphatidylserine at elevated cytosolic [Ca2+], implying an underlying defect or deficiency of PL scramblase. To gain insight into the molecular basis of this disorder, we compared PL scramblase in Scott erythrocyte membranes to those of normal controls. Whereas membranes of Scott cells were unresponsive to Ca2+-induced activation of PL scramblase at neutral pH, apparently normal PL scramblase activity was induced at pH < 6.0. After extraction with octylglucoside, a membrane protein was isolated from the Scott cells which exhibited normal PL scramblase activity when reconstituted in vesicles with exogenous PLs. Like PL scramblase from normal erythrocytes, PL scramblase from Scott erythrocytes was maximally activated either by addition of Ca2+ (at pH 7.4) or by acidification to pH < 6.0, and similar apparent affinities for Ca2+ and rates of transbilayer transfer of PLs were observed. This suggests that the defect in Scott syndrome is related to an altered interaction of Ca2+ with PL scramblase on the endofacial surface of the cell membrane, due either to an intrinsic constraint upon the protein preventing interaction with Ca2+ in situ, or due to an unidentified inhibitor or cofactor in the Scott cell that is dissociated by detergent. Minimize

Year of Publication:

1997-05-01

Document Type:

Text

Language:

en

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Research Article

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Title:

Autologous blood donor screening indicated a lower prevalence of viral hepatitis in East vs West Germany : epidemiological benefit from established health resources

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Wiegand, J. ; Luz, B. ; Mengelkamp, A. K. ; Moog, R. ; Koscielny, J. ; Halm-Heinrich, I. ; Susemihl, C. ; Bentzien, F. ; Diekmann, Jürgen ; Wernet, D. ; ...

Wiegand, J. ; Luz, B. ; Mengelkamp, A. K. ; Moog, R. ; Koscielny, J. ; Halm-Heinrich, I. ; Susemihl, C. ; Bentzien, F. ; Diekmann, Jürgen ; Wernet, D. ; Karger, R. ; Angert, K. ; Schmitt-Thomssen, A. ; Kiefel, V. ; Lutter, K. ; Hesse, R. ; Kätzel, R. ; Opitz, A. ; Luhm, J. ; Barz, D. ; Leib, U. ; Matthes, G. ; Tillmann, H. L. Minimize authors

Year of Publication:

2009-01-01

Document Type:

http://purl.org/dc/dcmitype/Text ; info:eu-repo/semantics/article ; doc-type:article

Language:

eng

Subjects:

HIV Antibodies ; Hepatitis B Surface Antigens ; Female ; blood transfusion ; Autologous ; Prevalence ; Humans ; Hepacivirus ; Germany ; East ; Hepatitis ; Viral ; Human ; HIV Infections ; Male ; Mass Screening ; Hepatitis B virus ; West ; HIV ; Health Resources ; syphilis ; geographic difference ; Autologous blood donors ; hepatitis C virus ; IN...

HIV Antibodies ; Hepatitis B Surface Antigens ; Female ; blood transfusion ; Autologous ; Prevalence ; Humans ; Hepacivirus ; Germany ; East ; Hepatitis ; Viral ; Human ; HIV Infections ; Male ; Mass Screening ; Hepatitis B virus ; West ; HIV ; Health Resources ; syphilis ; geographic difference ; Autologous blood donors ; hepatitis C virus ; INFECTIONS ; GENERAL-POPULATION ; LIVER-DISEASE ; HBV Minimize

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urn:issn:1352-0504 ; Journal of viral hepatitis

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